Alpha Lipoic Acid

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10 Best Alpha Lipoic Acid (ALA) Supplements for 2021

If you’re looking for the best alpha lipoic acid supplements to buy this year, then you’ve come to the right place.

You can also get more info by jumping to our Alpha Lipoic Acid Supplements Guide.

Doctor's Best Alpha-Lipoic Acid

Doctor's Best Alpha-Lipoic Acid, Non-GMO, Gluten Free, Vegan, Soy Free, Helps Maintain Blood Sugar Levels, 600 mg 180 Veggie Caps

  • DOCTOR’S BEST ALPHA-LIPOIC ACID (ALA) – plays an important role in the metabolism of glucose that produces cellular energy in the body. ALA is naturally occurring and functions as an antioxidant throughout the body that helps regenerate other antioxidants such as vitamin C, vitamin E and glutathione. ALA helps support the body’s potential in buffering free radicals for overall well-being.
  • SUPPORT YOUR BODY WITH ANTIOXIDANTS – ALA is a powerful antioxidant and supports the regeneration of antioxidants. Alpha lipoid acid also appears to function as a coenzyme in both antioxidant and metabolic functions. Potent antioxidant that is both a water-soluble and fat-soluble antioxidant.
  • SUPPORTS THE BODY’S DEFENSE AGAINST FREE RADICALS – recycles antioxidants such as Vitamin C and Vitamin E that have the ability to quench a wide variety of free radicals. Also supports the functioning of other antioxidants that are present in tissues and cells.

3,619 ratings
NOW Supplements, Alpha Lipoic Acid 250 mg, Supports Glutathione Production

NOW Supplements, Alpha Lipoic Acid 250 mg, Supports Glutathione Production*, Free Radical Scavenger*, 120 Veg Capsules

  • SUPPORTS GLUTATHIONE PRODUCTION*: Alpha lipoic acid (ALA) is naturally produced in the human body in very small amounts, but is also available through food sources.
  • TAKE 1 CAPSULE DAILY: ALA is unique because it supports the body’s free radical scavenging systems and can function in both water and fat environments.*
  • NON-GMO: ALA can also recycle the antioxidant vitamins C and E, thereby extending their activities.*
  • GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
  • Packaged in the USA by a family owned and operated company since 1968.

2,649 ratings
Source Naturals Alpha Lipoic Acid - Supports Healthy Sugar Metabolism, Liver Function & Energy Generation - 120 Time Release Tablets

Source Naturals Alpha Lipoic Acid - Supports Healthy Sugar Metabolism, Liver Function & Energy Generation - 120 Time Release Tablets

  • ULTIMATE PROTECTION. It is a critical component of an enzyme that generates acetyl coenzyme A, the start of the Krebs cycle that produces ATP in the mitochondria. ATP is the main source of energy for all muscle contractions and almost all other activities that our cells perform. Most of all, ALA is recognized as a powerful antioxidant because it has the unique ability to reactivate helpful compounds like vitamin C, glutathione, vitamin E, and CoQ10, enabling them to do more for your health.
  • SUPPORT YOUR BODY WITH ANTIOXIDANTS. It is a potent antioxidant and is active in both fat- and water-soluble regions of the cells. This makes ALA quite rare and this is why it is called “the universal antioxidant.” ALA also supports healthy sugar metabolism, liver function and energy generation.

4,638 ratings
Alpha Lipoic Acid Antioxidant Protection Promotes Healthy Blood Sugar Supplement 300 mg 120 Capsules

Alpha Lipoic Acid Antioxidant Protection Promotes Healthy Blood Sugar Supplement 300 mg 120 Capsules

  • HEALTHY BLOOD GLUCOSE SUPPORT – Alpha lipoic acid is an essential compound when it comes to supporting a healthy glucose metabolism. That’s because alpha-lipoic acid appears to help your body support neurons and cells that are vital to producing hormones while supporting healthy insulin levels.
  • FEATURES THE MASTER ANTIOXIDANT – Taking an alpha lipoic acid supplement is a great way to load up on free radical fighting antioxidants, but did you know that alpha lipoic acid supports the “master antioxidant” known as glutathione? Glutathione is naturally produced by the liver and plays an instrumental role in regulating the body’s immune response, promoting tissue building, and repair and supporting the production of vital proteins and chemicals.
  • ENHANCES ANTIOXIDANT ACTIVITY – This alpha lipoic acid supplement offers powerful free radical fighting support while also enhancing the activity of other antioxidants like Vitamin C and Vitamin E to support the body’s defense against damage-causing free radicals. Alpha lipoic acid provides both fat-soluble and water-soluble antioxidant protection too. Each capsule of Swanson Alpha Lipoic Acid contains 300 mg of alpha-lipoic acid.

1,528 ratings
Nutricost Alpha Lipoic Acid 600mg Per Serving, 240 Capsules - Gluten Free, Vegetarian Capsules, Soy Free & Non-GMO

Nutricost Alpha Lipoic Acid 600mg Per Serving, 240 Capsules - Gluten Free, Vegetarian Capsules, Soy Free & Non-GMO

  • Alpha Lipoic Acid – 240 Capsules Per Bottle; 120-240 Servings Per Bottle
  • 600mg of Potent, High Quality Alpha Lipoic Acid Per Serving (300mg Capsules)
  • Vegetarian Capsules
  • Non-GMO, Gluten Free, Soy Free, Vegetarian Friendly, And 3rd Party Tested
  • Made In a GMP Compliant, FDA Registered Facility

5,376 ratings
Natrol Alpha Lipoic Acid Tr 600mg Tablets, 45-Count

Natrol Alpha Lipoic Acid Tr 600mg Tablets, 45-Count

  • ANTIOXIDANT PROTECTION – The antioxidant powers infused in Natrol Alpha Lipoic Acid helps cells in the human body rejuvenate.*
  • NEUTRALIZE FREE RADICALS – Alpha lipoic acid has been shown to neutralize free radicals, as it’s a powerful antioxidant.
  • REDUCES OXIDATIVE STRESS – As an antioxidant, Alpha Lipoic Acid is known for its ability to reduce cellular damage and oxidative stress in the body, which helps to protect against age-related damages.
  • FUNCTIONS IN WATER & FAT – Unlike most antioxidants, like vitamins C and E, Natrol Alpha Lipoic Acid functions in both water and fat – making it a more robust and effective antioxidant.
  • SUPPORTS BLOOD SUGAR HEALTH* – Alpha Lipoic Acid is important for blood sugar health, encouraging glucose uptake by the body’s cells.

4,583 ratings
Solgar – Alpha Lipoic Acid 600 mg, 50 Tablets

Solgar – Alpha Lipoic Acid 600 mg, 50 Tablets

  • EXCELLENT ANTIOXIDANT: Alpha Lipoic Acid is a coenzyme as well as one of the most important antioxidants. It’s referred to as the universal antioxidant due to it being water and fat-soluble which enables it to function in both the aqueous and membrane parts of cells
  • GLUTATHIONE SUPPORT: Alpha Lipoic Acid supports the regeneration of one of the body’s primary antioxidants, glutathione
  • ADDITIONAL BODY BENEFITS: Alpha Lipoic Acid helps to recycle glutathione, Vitamins C and E, and Coenzyme Q10. In addition it helps the body fight cell damaging free radicals, helps the body metabolize sugar and supports healthy nerve function
  • KOSHER, GLUTEN FREE & SUITABLE FOR VEGANS: All vegetable capsules are KOF-K Kosher certified, non-GMO and certified gluten free. They are free of: gluten, wheat, dairy, yeast, sugar, and sodium. They are also free of artificial flavors, sweeteners, and preservatives

4,583 ratings

Nature Made Alpha Lipoic Acid 200mg Softgels, 30 Count for Antioxidant Support

  • For a limited time, you may receive either bottle while we update our packaging. Both have the same great product inside. Based on new FDA regulations, you may also notice a change in the unit of measure and/or daily value for certain products.
  • Contains a 30-day supply of Nature Made Alpha Lipoic Acid 200 mg Softgels, 30 softgels per bottle.
  • Antioxidant activity that helps neutralize free radicals
  • Adults, take 1 softgel daily with water on an empty stomach.
  • These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

3,529 ratings
Puritans Pride Alpha Lipoic Acid 600 Mg, 120 Count

Puritans Pride Alpha Lipoic Acid 600 Mg, 120 Count

  • Promotes antioxidant support
  • Helps us produce usable energy from food
  • Supports sugar metabolism
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers’ recommendations, when provided.

3,529 ratings

Alpha Lipoic Acid Reviews & Buying Guide

Alpha Lipoic Acid Supplements Guide

Alpha lipoic acid supplements are becoming increasingly popular with people who are looking to get more antioxidants, combat symptoms of diabetes and diabetic neuropathy, slow the damage done by liver disease or HIV, or to boost brain power.

While studies are still being conducted to determine how Alpha lipoic acid benefits people with certain disorders and diseases (as well as those who wish to lose weight), Alpha lipoic acid supplements seem to have some verifiable benefits. Read on to find out why Alpha lipoic acid supplements are being stocked on grocery and pharmacy shelves nationwide.

What Are Alpha Lipoic Acid Supplements?

The most important thing to know is what Alpha Lipoic Acid is and how it works in supplement form. Alpha lipoic acid is an antioxidant that helps to protect the body from damage caused by free radicals. Alpha lipoic acid also restores levels of vitamins C and E, which are essential for the body to properly function.

Taken in supplement form, Alpha lipoic acid is used to treat a number of symptoms of various diseases and disorders. In fact, some research suggests that Alpha lipoic acid helps to stimulate the functioning of neurons in those with diabetes. Many times, Alpha lipoic acid is combined with other function-boosting ingredients to form supplement complexes.

For example, Alpha lipoic acid is commonly paired with Acetyl-l-carnitine in supplements targeted at enhancing mental functioning and creating energy within the body. Alpha lipoic acid supplements are sold in stores and pharmacies as well as online through websites like Amazon and specific brand websites.


As with any supplement that you can buy over the counter, you should always consult your doctor first to see whether taking Alpha lipoic acid supplements might work for (or against) you. It is not recommended that children, women who are pregnant, women who are trying to become pregnant, or women who are lactating use these supplements since it is unknown how they might affect babies and children.

Anyone taking other medication should first consult with their doctor. Alpha lipoic acid supplements are known to moderately interact with cancer medications and might have minor interactions with diabetes medications since these supplements, like diabetes medications, lower blood sugar levels. Taking both at the same time could potentially lower your blood sugar too much.

On the whole, Alpha lipoic acid supplements are safe for most people to take at the recommended dosage. Some who have orally taken Alpha lipoic acid supplements report getting rashes on their skin. Nausea is another commonly reported side effect. Less commonly reported but far more serious are feeling like passing out, if you feel extremely dizzy, or if you experience intense hunger that cannot be satiated with food. If these more serious side effects occur, stop taking Alpha lipoic acid supplements and call your doctor.

Taking Alpha Lipoic Acid Supplements

As with any supplement or medication, you should always take it as recommended on the packaging or as directed by your doctor. Do not exceed the daily dosage listed on the package. Doing so can be dangerous and might cause side effects to emerge.

If you are using Alpha lipoic acid supplements to treat Type 2 diabetes symptoms, a recommended daily dosage is anywhere between 600 and 1200 mg. Directions might differ based on the brand producing the supplements. For example, Pure Encapsulations recommends that consumers use anywhere between 100 and 1200 mg per day, divided into dosages, to be taken with meals. Some users like to take 600 mg with breakfast in the morning and 600 mg with dinner in the evening to alleviate their neuropathy symptoms.

What to Look for in a Good Alpha Lipoic Acid Supplement

When you are shopping around for a brand of Alpha lipoic acid supplements to try, there are a few important factors that you need to consider before making your final selection. First and foremost, always consider any directions given to you by your doctor. Your doctor might have a preferred brand they recommend, and doctors tend to recommend what they feel has already demonstrated the best results in their patients.

If your doctor does not have any recommendations, check out what other consumers are saying online. You will find some brutally honest and insightful reviews left by customers who have already tried the brands of Alpha lipoic acid supplements you are looking at. While some reviews should be taken with a grain of salt, there can be trends that emerge when looking at online reviews.

If you notice that a particular brand of Acid lipoic acid supplements consistently seems to cause negative side effects like vomiting or fainting, you might want to try something else. You can also ask your local pharmacist what they sell on their shelves and which brand(s) they prefer.

Secondly, you should consider whether you want to take straight Alpha lipoic acid supplements or if a complex (such as a combined formula with Acetyl-l-carnitine) might work better. Again, ask your doctor and/or pharmacist for their recommendations.

Anyone with allergies to gluten or who is vegetarian or vegan should specifically look for gluten-free supplements that are manufactured with Hydroxypropyl methylcellulose (HPMC), which is a vegetarian alternative to gelatin capsules. Some supplements contain other allergens like soy and dairy, so you will need to carefully read the package of each bottle if you know you have these allergies or food sensitivities.

Finally, when you’re considering which Alpha lipoic acid supplement to buy, always check to make sure that the package is tightly sealed and that all of the pills contained within it look and smell normal. Some customers who have purchased these supplements online have reported getting botched products. Do not take anything that looks or smells suspicious.

Again, always make sure to contact your doctor when trying Alpha lipoic acid supplements, especially in conjunction with other medications and/or supplements. Alpha lipoic acid has many benefits, but science has yet to verify who exactly it can help and why it works so well for some people and not at all for others.